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Programme  Titles  Presenters 
S18 - The complex relationship between orthology, paralogy, and function
Monday 25th June 2012, 14:30-16:00
Wicklow 2a
O-157 Orthology: a simple concept marred in complexity but still holding
Eugene Koonin
National Center for Biotechnolgoy Information, NIH, USA
O-158 Changes in gene expression following segmental duplication in mammals
Katerina Guschanski*, Julien Meunier, Henrik Kaessmann
University of Lausanne, Switzerland
O-159 Exploring The Evolution Of Novel Enzyme Functions Within Structurally Defined Protein Superfamilies
Nicholas Furnham*1, Ian Sillitoe2, Gemma Holliday1, Alison Cuff2, Roman Laskowski1, Christine Orengo2, Janet Thornton1
1EMBL-EBI, UK, 2University College London, UK
O-160 Experimental annotations in 13 model organisms corroborate ortholog conjecture: orthologs tend to be weakly, but significantly, more similar in function than paralogs
Adrian Altenhoff1,2, Romain Studer2,3, Marc Robinson-Rechavi2,3, Christophe Dessimoz*1,4
1ETH Zurich, Switzerland, 2Swiss Institute of Bioinformatics, Switzerland, 3University of Lausanne, Switzerland, 4EMBL-EBI, UK
O-161 A comparative analysis of orthologs and paralogs in Animals: from sequence to structure.
Romain Studer*, Christine Orengo
University College London, UK